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SOMA Package on Space Biology is Now Publicly Available

SOMA features analyses from Inspiration4 mission. Credit: Inspiration4 Crew

Ibadan, 14 June 2024. – The Space Omics and Medical Atlas (SOMA) package of manuscripts, data, protocols, and code has been publicly released. The package represents the largest-ever compendium of data for aerospace medicine and space biology with more than 100 institutions from over 25 countries working together for a coordinated 2024 release of molecular, cellular, physiological, phenotypic, and spaceflight data.

The package includes analyses of samples from the Inspiration4 mission, which comprised commercial astronauts who embarked on a short-term mission to a high-altitude orbit (575 km). While in orbit, the Inspiration4 crew performed numerous scientific experiments, which have now undergone processing, sequencing, and analysis, contributing to most of the 44 papers in the SOMA package. SOMA also features analyses of data collected from JAXA studies, and NASA and ESA astronaut missions.

The package reports changes at the cellular, tissue, organismal, and systemic levels resulting from spaceflight. Furthermore, it begins to map differences in how female and male individuals respond to spaceflight and links specific countermeasures to each astronaut.

The SOMA package also features a >10-fold increase in the number of next-generation sequencing (NGS) data from spaceflight, a 4-fold increase in the number of single-cells processed from spaceflight, the launch of the first aerospace medicine biobank (Weill Cornell Medicine’s CAMbank). In addition, it includes the first-ever direct RNA sequencing data from astronauts, the largest number of processed biological samples from a mission (2,911), and the first-ever spatially-resolved transcriptome data from astronauts.

All raw and processed data from the crew during and after their missions are now available in NASA’s Open Science Data Repository an expansion of NASA GeneLab. Additionally, the project created four new data portals for browsing results from the mission, including linked data from the NASA Twins Study.

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